A super-sensitive test for Alzheimer's that could identify the disease long before symptoms appear has been demonstrated on patients, scientists have said.
The test is able to detect minute protein molecules called ADDLs which are thought to accumulate in the brain and trigger Alzheimer's.
Conventional tests are not sensitive enough to spot an ADDL, which stands for amyloid beta-derived diffusible ligand. The molecule is only five millionths of a millimetre (five nanometres) wide and present in cerebrospinal fluid at very low concentration.
Research suggests that ADDLs attack and disrupt synapses in the brain, the nerve cell connection sites vital to information processing and memory formation.
Tratto da APA - prosegui nella lettura dell'articolo