A study in teenagers showed the "reward hub", which is involved in addiction, was larger in regular player
A report in Translational Psychiatry said it was unknown if games changed the brain or if brain differences made people more likely to play.
Experts said more studies were needed for parents and teenagers to make sense of the findings.
Playing computer games has been linked to a range of effects from addiction to improved reasoning. An international group of researchers investigated whether playing changed the structure of the brain. They ranked 154 14-year-olds by the number of hours played in a week, with the middle teenagers playing about nine hours a week.
Those playing more than nine hours were classed as frequent players. None were classed as addicted.
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