According to a study from the Netherlands, "The central issue raised in this paper is: Can stress cause depression? Phrased more precisely: Can stress cause brain disturbances thought to underlie (certain forms of) depression or particular components of the depressive syndrome."
"Focusing on 5-hydroxytryptamine (5-HT) and the stress hormones, this question was answered in the affirmative, based on the following two considerations: Changes in the 5-HT and stress hormone systems produced by sustained stress mimic to a substantial extent the disturbances in these systems that may be observed in depression. Substantial evidence indicates that the 5-HT and stress hormone disturbances in depression are of pathophysiological significance and not merely a consequence of the depressed state or a product of stress generated by the depressed state," wrote H.M. Vanpraag and colleagues, Maastricht University, Academy Hospital Maastricht.
They continued: "Furthermore, the question was raised whether a depression type could be identified [as] particularly stress-inducible. This question, too, was answered in the affirmative. The depression type in question was named anxiety/aggression-driven depression and characterized on three levels: psychopathologically, biologically, and psychologically. Preferential treatment of this depression type was discussed."
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