In the manic stage, the patient often feels intense excitement and irritability, which can trigger unpredictable risky behavior. Work, family, and social life all can be impaired by this risk-taking.
Professor Wael El-Deredy of Manchester University, UK, and colleagues investigated the neuroscience behind this risky behavior. They engaged 20 individuals with bipolar disorder but not taking antipsychotic medication and 20 without bipolar disorder.
They measured with fMRI these individuals’ brain activity while playing a game of roulette. Participants were encouraged to make both safe and risky gambles in the game.
This showed “a dominance of the brain’s pleasure center” among those with bipolarhigh end hublot replica replica omega watches review fake patek philippe nautilus fake vacheron constantin overseas disorder, say the team. This area, the nucleus accumbens, drives us to seek out and pursue rewards, they explain, and is not under conscious control. Healthy participants had a less strongly activated nucleus accumbens than those with bipolar disorder.