Dementia plaques attack language center of brain

The research offers additional insight into why this type of dementia causes people to lose the ability to express themselves and understand language

The recent ability to peer into the brain of living individuals with a rare type of language dementia, primary progressive aphasia (PPA), provides important new insights into the beginning stages of this disease — which results in language loss — when it is caused by a buildup of a toxic protein found in Alzheimer’s disease.

Using a special imaging technique, Northwestern Medicine scientists have discovered the toxic build-up of amyloid protein is greater on the left side of the brain — the site of language processing — than on the right side in many individuals living with PPA.

Previously, amyloid accumulation in the brain could only be studied after an individual with Alzheimer’s disease had died.

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